منابع مشابه
Posterior Corneal Steepening in Posterior Polymorphous Corneal Dystrophy.
PURPOSE The aim was to evaluate the anterior and posterior corneal topographic characteristics of three patients with posterior polymorphous corneal dystrophy (PPCD) using a rotating Scheimpflug camera combined with a Placido disc system (Sirius, CSO, Italy). CASE REPORTS Two children with unilateral PPCD and a 53-year-old woman with bilateral PPCD were diagnosed by the presence of vesicles a...
متن کاملPunctiform and polychromatic pre-Descemet's dominant corneal dystrophy.
A new type of pre-Descemet's corneal dystrophy is described. The opacities are punctiform, polychromatic, of uniform size, and evenly distributed over the whole cornea. The diagnosis is made only by slit lamp because there is no visual impairment. The disease is hereditary and follows the autosomal mode of inheritance with a high percentage of penetrance, expressivity, and specificity in 4 succ...
متن کاملTranscriptomic Profiling of Posterior Polymorphous Corneal Dystrophy
Purpose To investigate the molecular basis of posterior polymorphous corneal dystrophy (PPCD) by examining the PPCD transcriptome and the effect of decreased ZEB1 expression on corneal endothelial cell (CEnC) gene expression. Methods Next-generation RNA sequencing (RNA-seq) analyses of corneal endothelium from two PPCD-affected individuals (one with PPCD3 and one of unknown genetic cause) com...
متن کاملEpithelialization of the corneal endothelium in posterior polymorphous dystrophy.
The unusual cell type present on the posterior corneal surface of posterior polymorphous dystrophy patients has been characterized. In addition to microvilli and desmosomes, these cells contain abundant 10 nm filaments which by immunofluorescent staining were shown to consist of keratin proteins, a marker for epithelial cells.
متن کاملZeb1 mutant mice as a model of posterior corneal dystrophy.
PURPOSE The zinc finger transcription factor Zeb1 binds to E-box-like sequences and is important for maintaining repression of epithelial specification genes in vivo. Overexpression of Zeb1 in cancer triggers epithelial-mesenchymal transition, which facilitates metastasis. The mutation of ZEB1 in humans is linked to posterior polymorphous corneal dystrophy (PPCD), in which an epithelial transit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Revista Brasileira de Oftalmologia
سال: 2015
ISSN: 0034-7280
DOI: 10.5935/0034-7280.20150039